Asymmetric Intramolecular Arylcyanation of Unactivated Olefins via C−CN Bond Activation
نویسندگان
چکیده
منابع مشابه
Asymmetric Intramolecular Carbocyanation of Unsaturated Olefins via C-C Bond Activation**
Every organic functional group coordinates with each transition metal in a characteristic manner. Upon coordination, the reactivity of these functional groups is often dramatically altered. In this way the normal reactivity patterns of functional groups can be inverted, and unconventional transformations can be achieved with facility. Most organometallic reactions are highly specific, able to d...
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A solution to the classic unsolved problem of olefin hydromethylation is presented. This highly chemoselective method can tolerate labile and reactive chemical functionalities and uses a simple set of reagents. An array of olefins, including mono-, di-, and trisubstituted olefins, are all smoothly hydromethylated. This mild protocol can be used to simplify the synthesis of a specific target or ...
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Metal-catalyzed enantioselective intramolecular hydroamination of olefins1 is one of the most conceptually simple and atom-economical approaches to the construction of enantioenriched nitrogen heterocycles,2 which are valuable synthons in the preparation of natural products and biologically active molecules.3 Despite significant advances,4,5,6 no general solution for this challenging transforma...
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The inclusion of fluorinated functional groups in small molecules has had a profound impact on the pharmaceutical, material, and agrochemical industries.[1, 2] In particular, the trifluoromethyl (CF3) substituent has emerged as an important functional group for the modulation of the physical properties in new pharmaceutical candidates as it has excellent metabolic stability, lipophilicity, and ...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2008
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja805094j